The autonomic nervous system, also known as the involuntary nervous system, regulates those facets in the body that occur automatically, such as breathing, blood pressure, digestion, heart beat, bladder function and narrowing or widening of the blood vessels. It appears that the curcumin exerts its anti-carcinogenic activity by lowering the activation of carcinogens while increasing the detoxification of those that are activated. An Organic Acids test is a good place to start for identifying nutritional deficiencies. Around the end of the 12 th week of growing your cannabis, you should be ready to harvest your crop. Thyroid — this is your organ of metabolism, when in balance neither running too high, too hot or too low, too cold your immune system is maintained, your digestion is good, your blood pressure, blood sugar and cholesterol tend to be normal. Pineal- controls sleep and immune function.
2 Parts of the Autonomic Nervous System
This is called the conjugation pathway, whereby the liver cells add another substance eg. This makes the toxin or drug water-soluble, so it can then be excreted from the body via watery fluids such as bile or urine. Major Phase II pathways include glutathione, sulfate, glycine, and glucuronide conjugations. Individual xenobiotics and metabolites usually follow one or two distinct pathways. Again, this makes testing of the various pathways possible by challenging with known substances.
The conjugation molecules are acted upon by specific enzymes to catalyse the reaction step. Through conjugation, the liver is able to turn drugs, hormones and various toxins into excretable substances. For efficient phase two detoxification, the liver cells require sulphur-containing amino acids such as taurine and cysteine.
The nutrients glycine, glutamine, choline and inositol are also required for efficient phase two detoxification. Eggs and cruciferous vegetables eg. Thus, these foods can be considered to have a cleansing action. Glutathione is the most powerful internal antioxidant and liver protector. Phase II reactions may follow Phase I for some molecules or act directly on the toxin or metabolite. Good picture of Phase II conjugation reactions: Phase II detoxification typically involves conjugation in which various enzymes in the liver attach small chemicals to the toxin.
This conjugation reaction either neutralizes the toxin or makes the toxin more easily excreted through the urine or bile. Phase II enzymes act on some toxins directly, while others must first be activated by the phase I enzymes.
There are essentially six phase II detoxification pathways: In order to work, these enzyme systems need nutrients both for their activation and to provide the small molecules they add to the toxins.
In addition, they utilize metabolic energy to function and to synthesize some of the small conjugating molecules. Thus, mitochondrial dysfunction, such as found in chronic fatigue syndrome, a magnesium deficiency or physical inactivity, can cause phase II detoxification to slow down, allowing the build-up of toxic intermediates.
Glutathione, vitamin B6 Amino acid conjugation: Cysteine, methionine, molybdenum Acetylation: Brassica family foods cabbage, broccoli, Brussels sprouts ; limonene-containing foods citrus peel, dill weed oil, caraway oil Amino acid conjugation: Lipotropic nutrients choline, methionine, betaine, folic acid, vitamin B12 Sulfation: Cysteine, methionine, taurine Acetylation: Fish oils, cigarette smoking, birth control pills, Phenobarbital, limonene-containing foods.
Inhibition of phase II detoxification is not desired, especially in those with Gilbert's Syndrome, as these enzymes are already inhibited. Selenium deficiency, vitamin B2 deficiency, glutathione deficiency, zinc deficiency Amino acid conjugation: Low protein diet Methylation: Folic acid or vitamin B12 deficiency Sulfation: Non-steroidal anti-inflammatory drugs e. Vitamin B2, B5, or C deficiency Glucuronidation: Glucuronidation is a major phase II detoxification pathway in which the sugar moiety of UDP-glucuronic acid is covalently linked to a xenobiotic or endobiotic, facilitating its removal from the body in the urine or bile.
The directed excretion of glucuronides from the lumen of the endoplasmic reticulum ER to the plasma membrane and the exterior of the cell is an important regulated process. Impaired excretion leads to liver damage. Specific transporters for excretion of glucuronides have been implicated in lever cell function in ER and bile canaliculus. Polycyclic aromatic hydrocarbons, steroid hormones, some nitrosamines, heterocyclic amines, some fungal toxins, and aromatic amines.
It also removes "used" hormones, such as estrogen and T4 thyroid hormone that are produced naturally by the body. Many of the commonly prescribed drugs are detoxified through this pathway. It also helps to detoxify aspirin, menthol, vanillin synthetic vanilla , food additives such as benzoates, and some hormones. Glucuronidation appears to work well, except for those with Gilbert's syndrome--a relatively common syndrome characterized by a chronically elevated serum bilirubin level 1. The condition is usually without serious symptoms, although some patients do complain about loss of appetite, malaise, and fatigue typical symptoms of impaired liver function.
The main way this condition is recognized is by a slight yellowish tinge to the skin and white of the eye due to inadequate metabolism of bilirubin, a breakdown product of hemoglobin. The activity of UDPGT is increased by foods rich in the monoterpene limonene citris peel, dill weed oil, and caraway oil.
Methionine, administered as SAM, has been shown to be quite beneficial in treating Gilbert's syndrome. Glucuronidation is a major inactivating pathway for a huge variety of exogenous and endogenous molecules, including drugs, polluants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids and bile acids.
These enzymes are primarily found in the endoplasmic reticulum of many tissues, with the liver being, quantitatively, the most significant site of glucuronidation.
In addition to a wide tissue distribution of UGTs, different isozymes can be preferentially expressed in specific tissues. Furthermore, polymorphic expression of certain UGTs has also been observed 2.
Of these three families UGT1 and UGT2 have been shown to catalyze the glucuronidation of a wide variety of xenobiotic substrates, with UGT1 being more active in the glucuronidation of amines 3,4. Aryl- and alkylamines, sulfonamides, heterocyclic amines and hydroxylated compounds have all been reported to undergo glucuronidation in many animal species and humans.
The primary function of UGTs is to eliminate substrates from the body via urine and feces by catalyzing the formation of hydrophilic glucuronide conjugates 5. UGT detoxifies many xenobiotics. The UGT1 family specializes in processing amines, arylamines and alkylamines, sulfonamides, heterocyclic amines and hydroxylated compounds. UDP-glucuronosyltransferases UGTs belong to a superfamily of microsomal enzymes responsible for glucuronidation of numerous endogenous and exogenous compounds including bilirubin, hormones, various drugs as well as environmental carcinogens.
Glucuronidation predominantly serves as a pathway for elimination of the different glucuronidated compounds. Seventeen human UGT transcripts have been identified thus far, and the UGT proteins are differentially expressed in a wide-range of human tissues. Most of the UGTs are expressed in the liver as well as other extrahepatic tissues; however, some are exclusively extrahepatic Table 1.
The tissue specific regulation of UGTs ensures a unique complement of UGT proteins to various tissues, and defines the capacity of each tissue's ability to eliminate or inactivate various exogenous and endogenous substrates. A primary phase II detoxification route is conjugation with glutathione a tripeptide composed of three amino acids--cysteine, glutamic acid, and glycine. Glutathione conjugation produces water-soluble mercaptates which are excreted via the kidneys. The elimination of fat-soluble compounds, especially heavy metals like mercury and lead, is dependent upon adequate levels of glutathione, which in turn is dependent upon adequate levels of methionine and cysteine.
When increased levels of toxic compounds are present, more methionine is utilized for cysteine and glutathione synthesis. Methionine and cysteine have a protective effect on glutathione and prevent depletion during toxic overload. This, in turn, protects the liver from the damaging effects of toxic compounds and promotes their elimination. Glutathione is also an important antioxidant.
This combination of detoxification and free radical protection, results in glutathione being one of the most important anticarcinogens and antioxidants in our cells, which means that a deficiency is cause of serious liver dysfunction and damage. Exposure to high levels of toxins depletes glutathione faster than it can be produced or absorbed from the diet. This results in increased susceptibility to toxin-induced diseases, such as cancer, especially if phase I detoxification system is highly active.
Disease states due to glutathione deficiency are not uncommon. A deficiency can be induced either by diseases that increase the need for glutathione, deficiencies of the nutrients needed for synthesis, or diseases that inhibit its formation. Smoking increases the rate of utilization of glutathione, both in the detoxification of nicotine and in the neutralization of free radicals produced by the toxins in the smoke.
Glutathione is available through two routes: Dietary glutathione found in fresh fruits and vegetables, cooked fish, and meat is absorbed well by the intestines and does not appear to be affected by the digestive processes.
Dietary glutathione in foods appears to be efficiently absorbed into the blood. However, the same may not be true for glutathione supplements. In healthy individuals, a daily dosage of mg of vitamin C may be sufficient to elevate and maintain good tissue glutathione levels. Vitamin C raises glutathione by increasing its rate of synthesis.
In addition, to vitamin C, other compounds which can help increase glutathione synthesis include N-acetylcysteine NAC , glycine, and methionine. In an effort to increase antioxidant status in individuals with impaired glutathione synthesis, a variety of antioxidants have been used.
Over the past years, the use of NAC and glutathione products as antioxidants has become increasingly popular among nutritionally oriented physicians and the public. While supplementing the diet with high doses of NAC may be beneficial in cases of extreme oxidative stress e. AIDS, cancer patients going through chemotherapy, or drug overdose , it may be an unwise practice in healthy individuals.
Glutathione-S-transferase detoxifies many water-soluble environmental toxins, including many solvents, herbicides, fungicides, lipid peroxides, and heavy metals e. The various forms of GST work together to eliminate toxins. Decreased glutathione conjugation capacity may incrase toxic burden and increase oxidative stress. Glutathione-S-tranferase affords protection against oxidative stress especially by reducing hydrogen peroxide and by regenerating oxidized vitamins C and E.
GST also detoxifies electrophilic compounds including solvents, herbicides, fungicides, polycyclic aromatic hydrocarbons and heavy metals Mercury, Lead, and Cadmium. Decreased glutathion conjugation capacity may increase toxic burden and increase oxidative stress resulting in a greater risk for various cancers and fatigue syndromes, especially if exposed to toxic compounds.
Regardless of genotype, increasing the body's production of glutathione will reduce oxidative stress and afford greater protection against a wide array of toxins.
Numerous supplements can help raise glutathione levels including liberal consumption of colorful vegetables and fruits, vitamin C, n-acetylcysteine and milk thistle.
Liberally consume bassica vegetables broccoli, cauliflower, kale, cabbage, bok choi, etc. Vitamin E supplementation may also be helpful. COnsult your healthcare provider to find the supplement regimen that best fits your overall health needs. If you smoke, stop. Avoid exposure to herbicides, fungicides, insect sprays and industrial solvents. Thymus-this is the heart of your immune system. Pancreas- this is your digestion source and blood sugar control center. Adrenals- this is where energy and immunity begin.
Hormones Melatonin — balances your immune system and metabolism to keep the fire burning so all enzymes and metabolic pathway perform to perfection — this is all controlled by light and dark cycles.
Insulin control brain chemistry and dopamine and serotonin levels that in turn affect your behavior and mood. When one goes out of balance they all go out of balance. Melatonin affects the pituitary gland function. Pituitary gland makes part or all of most of your hormones. When it is thrown out of balance it will affect your: Thyroid — metabolism, energy. Thymus — immune function.
Pancreas — blood sugar, appetite, immune function. Adrenals — stress management, pain control, immune function. The hypothalamus also initiates part of the adrenal stress response, causing the pituitary to secrete the hormone that travels to the adrenal glands to stimulate secretion of cortisol, Adrenal and other hormonal gland dysfunctions can cause some of the above symptoms and more, including cravings for sweets, weight gain, allergies, heart palpitations, insomnia, depression, fatigue, poor memory, foggy thinking, headaches, nervousness, inability to concentrate, recurrent infections and glucose intolerance.
Pituitary imbalance causes thyroid imbalance or dysfunction. Thyroid gland — causes the metabolism to slow and the body temperature will start to decrease. All enzymes for all cellular function that maintain your life are dependent on the As this decreases you decrease your immune system response, you decrease function of all other organs and glands, you gain weight, your bowels slow down, your thoughts become foggy, scattered, your memory fails.
Thymus gland -this is next in the endocrine connection. Decreased melatonin will affect a decrease in the immune function of the thymus causing either hyper overactive or hypo underactive immunity. T cells are the killer cells that get rid of bacteria, viruses, parasites, fungus and cancer cells. Adrenal glands -secrete adrenaline to prepare you for action, to give you energy and to boost your immune system, prevent pain. Thyroid Gland Referral pain area: Common Causes of Adrenal Stress: Stimulates the liver to convert amino acids to glucose, the primary fuel for energy production.
Stimulates increased glycogen in the liver. Glycogen is the stored form of glucose. Mobilizes and increases fatty acids in the blood from fat cells to be used as fuel for energy production. Counteracts inflammation and allergies. According to some research, water at different temperatures is good at balancing the nervous system. And there are some recommended therapies:. After reading the article of top 9 ways on how to strengthen nervous system health, hope that you can find out the best solutions to strengthen nervous system health naturally at home.
Nevertheless, the article is just for the informational purpose, thus, you should meet your expert to get advice before applying any natural way. If you have any question, or you know other good ways on how to strengthen nervous system health naturally, leave them below. How to get rid of nervousness and anxiety before a presentation.
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You can get magnesium from many kinds of food. These are some typical ones: Spinach, Swiss chard, lettuce. Banana, plum, melon, apricot, etc. Brown rice, oats, millet. Cashews, almonds, walnuts, hazelnuts, etc. Dark chocolate with mg of magnesium average per 3. Potatoes Seeds Pumpkin By another way, you can also take in the magnesium supplement, and remember your doctor to have a correct dosage.
Add Omega-3 Fatty Acids Omega-3 fatty acids are known as docosahexaenoic acid DHA and eicosapentaenoic acid EPA , which are very important for the nervous system to develop and function its role. There are 2 common ways for you to take in omega 3- fatty acids: Eat foods rich in omega-3 such as salmon, cauliflower, spinach, Brussels, canola oil, chia seeds, flaxseeds, walnuts, sardines.
Take in omega-3 with supplements according to the direction of your doctor. Supply Optimal Nutritional Support Your brain, peripheral nerves and spinal cord and are covered by a layer of fat that is called myelin. Breathe Deeply Breathing deeply is always a simple but effective way to treat a weak nervous system. These are the steps you should follow: Sit or lie down in a suitable position and put your hands on the abdomen. Make a deep breathe with your nose so that your abdomen will be expanded and your lungs will be filled with air.
Hold your breath for 3 seconds and then breathe it out slowly through your mouth so that your lungs will be completely empty. Continue to the deep inhaling and exhaling procedure for 5 to 10 minutes. Enjoy the deep breathing 2 or 3 times a day. How to stop mouth breathing while sleeping at night — 8 tips 5. Walk On Barefoot Walking barefoot on natural environment such as soft grass, sandy beach regularly is very good for your nervous system.
Yoga And Mediation You can make yoga and meditation as a part of your daily activities because this is also another way on how to strengthen nervous systems health naturally at home.
How to combat anxiety attack naturally 7. Expose To The Sunlight This is one of the simplest ways on how to strengthen nervous systems health naturally at home that you must do. You should absorb the sunlight by 1 of 2 ways below: Expose your body to the early morning sunlightwhile not using any sunscreen. Get vitamin D from some kinds of food such as milk, eggs, salmon, tuna, or cereals that are rich in vitamin D.